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ICR/Mlac-Free Hydro

Written by Super User. Posted in Animals

Name ICR/Mlac-Free Hydro
Sciencetific Name Mus  musculus
Strain ICR Hydronephrosis Inbred mouse
Source National Laboratory Animal Center established since (1992)
Coat color Albino
Biological Data  
Adult body weight 

Male 25-40 grams,Female  20-35 grams.
Average life span 2-2.5 years.
Age at mating

Male 6-8 weeks (25-40 grams) , Female 6-8 weeks (25-35 grams)
Estrous cycle  4-5 days
Duration of estrus 10 hours
Reproductive time 8-9 months
Gestation period  19-21 days
Weaning age  19-21 days (10-14 grams)
Litter size 1-14 pups (average 7)
Normal birth weight  1-1.5 grams
Post partum estrus  - NO -
Food consumption  3-6 grams/animal/day (Adult)
Water consumption 

3-8 ml/animal/day (Adult)
Nipples  10,3 Pairs on the thorax, 2 Pairs on the abdomen.
Eyes open  12 days
Growth rate  - NO -

Husbandry

Breeding Systems

Brother-syster selective mating system is used to maintain ICR Free hydronephrosis mouse in foundation stock.
 

Environment

                The ICR hydronephrosis mouse is housed in the controlled environment. The ventilation, temperature and humidity are controlled by HVAC (Heating, Ventilating, Air conditioning) system.  

- Temperature range at about 24 ± 2 ํC 

- Relative humidity is ranged between  55 + 10%

- Air changes per hour 10-15 ACH

- Light: and  dark cycle 12:12 hours

- Mouse is sensitive to noise so the noise level should be < 85 db.

Feed and water

           The Mlac:ICR is fed on the commercial diet (No. CP 082) product of Perfect companion group co. Ltd., the animal feed manufacturer which milled according to our requested specifications. Food is provided in stainless steel wire- bar lid feeders ad libitum. The RO Water is used for the drinking water which is chlorinated at a concentration of 10-12 ppm to make it free from Pseudomonas aeruginosa. The drinkingwater is provided in bottles with sipper tubes

Bedding

 Hard wood chips (or shaving) is used for mouse as bedding material. The same bedding is used in shipping containers. Dried bedding is packed in brown paper bags and sterilized by autoclave at 135 C for 7 minutes before used.

Equipment

The ICR Free hydronephrosis mouse used shoe box Cages by size as below   

Dimensions of Enclosure (W×L×H)(centimeter)

Maximum Number Animals/Enclosure

Types of Enclosure & Description

7.5 × 11.5 × 5

6 animals/cage (or) 1 animal (lactating female)/cage

Polysulfonate cages and stainless steel cages with stainless steel wire-bar lid

 

Experimental Uses

          The genetic background of this strain is similar to  ICR Outbred mouse strain of our Center but they are totally free from hydronephrosis mutant gene.